HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCNNA (Q61180)
Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Gene: Scnn1a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	12424229, 11742982, 18687683, 15123669
Identification Methods	far western blotting, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 699
+	Hs
		739604 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNA_HUMAN (26-696): 0: 763: 82.71
+	Hs
		739582 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNNA_HUMAN (26-696): 0: 763: 82.71
+	Mm
		93286 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNNG_MOUSE (79-693): 0: 624: 34.27
+	Hs
		845991 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNG_HUMAN (79-693): 0: 617: 33.81
+	Hs
		845978 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNB_HUMAN (79-695): 0: 589: 32.45
+	Mm
		93285 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNNB_MOUSE (79-695): 0: 572: 33.60
+	Mm
		1208291 NED4L_MOUSE (1-835): 0: 951: 97.54		SCNNB_MOUSE (79-695): 0: 572: 33.60
+	Hs
		808050 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNNG_HUMAN (79-693): 0: 617: 33.81
+	Hs
		808049 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNNB_HUMAN (79-695): 0: 589: 32.45
+	Rn
		739630 Q4V8H7_RAT (34-832): 0: 762: 36.59		SCNNG_RAT (79-693): 0: 634: 34.70
+	Hs
		739597 HUWE1_HUMAN (286-833): 3.77e-170: 548: 34.17		SCNNA_HUMAN (26-696): 0: 763: 82.71
+	Mm
		808356 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCNNA_MOUSE (1-699): 0: 819: 100.00
+	Hs
		739608 WWP1_HUMAN (6-182): 1.18e-28: 125: 22.28		SCNNA_HUMAN (26-696): 0: 763: 82.71
+	Hs
		125197 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCNNA_HUMAN (26-696): 0: 763: 82.71
+	Hs
		739596 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		SCNNA_HUMAN (26-696): 0: 763: 82.71
+	Hs
		125257 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCNNG_HUMAN (79-693): 0: 617: 33.81
+	Mm
		808383 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCNNG_MOUSE (79-693): 0: 624: 34.27
+	Hs
		125256 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCNNB_HUMAN (79-695): 0: 589: 32.45
+	Hs
		845975 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		SCNNB_HUMAN (79-695): 0: 589: 32.45
+	Mm
		808382 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCNNB_MOUSE (79-695): 0: 572: 33.60