HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCN9A (Q62205)
Sodium channel protein type 9 subunit alpha (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)
Gene: SCN9A

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	15123669
Identification Methods	far western blotting, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 1984
+	Mm
		69865 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN2A_MOUSE (2-1983): 0: 1987: 77.33
+	Mm
		93284 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN8A_MOUSE (3-1983): 0: 1849: 68.34
+	Hs
		723839 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN1A_HUMAN (2-1979): 0: 1948: 76.03
+	Mm
		93283 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN5A_MOUSE (4-1979): 0: 1822: 60.72
+	Hs
		1055040 NED4L_HUMAN (1-835): 0: 944: 95.79		SCN5A_HUMAN (4-1979): 0: 1815: 60.35
+	Mm
		93276 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNAA_MOUSE (4-1984): 0: 1772: 53.77
+	Hs
		808322 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN8A_HUMAN (3-1983): 0: 1850: 68.59
+	Hs
		808128 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN5A_HUMAN (4-1979): 0: 1815: 60.35
+	Hs
		808340 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNAA_HUMAN (4-1982): 0: 1730: 54.37
+	Mm
		808358 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN9A_MOUSE (1-1984): 0: 2064: 100.00
+	Hs
		1079738 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN9A_HUMAN (1-1983): 0: 2036: 92.90
+	Mm
		69867 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN2A_MOUSE (2-1983): 0: 1987: 77.33
+	Hs
		723851 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN1A_HUMAN (2-1979): 0: 1948: 76.03
+	Hs
		1055045 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN5A_HUMAN (4-1979): 0: 1815: 60.35
+	Hs
		125457 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCN5A_HUMAN (4-1979): 0: 1815: 60.35
+	Mm
		93270 E9PXB7_MOUSE (1-835): 0: 959: 100.00		Q3UF73_MOUSE (2-199): 4.39e-99: 318: 78.79
+	Hs
		1047217 NED4L_HUMAN (1-835): 0: 944: 95.79		CAC1C_HUMAN (22-537): 5.27e-19: 96.9: 15.60
+	Mm
		808349 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		Q3UF73_MOUSE (2-199): 4.39e-99: 318: 78.79
+	Hs
		132322 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		CAC1A_HUMAN (30-691): 1.73e-24: 114: 14.97
+	Hs
		125445 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		CAC1C_HUMAN (22-537): 5.27e-19: 96.9: 15.60