HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCNAA (Q6QIY3)
Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (Sensory neuron sodium channel) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)
Gene: Scn10a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 1958
+	Mm
		69865 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN2A_MOUSE (5-1953): 0: 1796: 52.78
+	Hs
		808340 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNAA_HUMAN (1-1957): 0: 1901: 82.23
+	Mm
		93283 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN5A_MOUSE (5-1948): 0: 1762: 60.83
+	Mm
		93274 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN9A_MOUSE (5-1950): 0: 1752: 52.77
+	Hs
		1055040 NED4L_HUMAN (1-835): 0: 944: 95.79		SCN5A_HUMAN (5-1948): 0: 1751: 59.91
+	Mm
		93284 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN8A_MOUSE (5-1953): 0: 1702: 52.45
+	Hs
		808128 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN5A_HUMAN (5-1948): 0: 1751: 59.91
+	Hs
		723839 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN1A_HUMAN (5-1943): 0: 1740: 52.59
+	Hs
		808322 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN8A_HUMAN (5-1953): 0: 1694: 52.21
+	Mm
		808363 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCNAA_MOUSE (1-1958): 0: 1992: 100.00
+	Mm
		69867 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN2A_MOUSE (5-1953): 0: 1796: 52.78
+	Hs
		1055045 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN5A_HUMAN (5-1948): 0: 1751: 59.91
+	Mm
		808378 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN5A_MOUSE (5-1948): 0: 1762: 60.83
+	Hs
		125457 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCN5A_HUMAN (5-1948): 0: 1751: 59.91
+	Hs
		723851 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN1A_HUMAN (5-1943): 0: 1740: 52.59
+	Mm
		808358 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN9A_MOUSE (5-1950): 0: 1752: 52.77
+	Hs
		1047217 NED4L_HUMAN (1-835): 0: 944: 95.79		CAC1C_HUMAN (21-525): 1e-19: 99.1: 13.65
+	Hs
		1079738 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN9A_HUMAN (625-1122): 1.73e-46: 186: 16.10
+	Hs
		125445 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		CAC1C_HUMAN (21-525): 1e-19: 99.1: 13.65
+	Hs
		132322 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		CAC1A_HUMAN (43-645): 5.84e-21: 103: 14.79