HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: ARBK1 (Q99MK8)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein-coupled receptor kinase 2)
Gene: Grk2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	17544362
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 835 Mm			1 689
+	Hs
		1299664 NED4L_HUMAN (1-835): 0: 944: 95.79		AKT3_HUMAN (69-517): 7.16e-141: 422: 27.23
+	Hs
		681988 NED4L_HUMAN (1-835): 0: 944: 95.79		AKT1_HUMAN (69-515): 8.96e-140: 419: 26.55
+	Hs
		808201 NEDD4_HUMAN (1-835): 0: 845: 60.41		GRK7_HUMAN (1-530): 1.27e-142: 429: 30.80
+	Hs
		687021 NEDD4_HUMAN (1-835): 0: 845: 60.41		GRK4_HUMAN (3-579): 1.13e-140: 425: 33.96
+	Hs
		808324 NEDD4_HUMAN (1-835): 0: 845: 60.41		AKT3_HUMAN (69-517): 7.16e-141: 422: 27.23
+	Hs
		681731 NEDD4_HUMAN (1-835): 0: 845: 60.41		AKT1_HUMAN (69-515): 8.96e-140: 419: 26.55
+	Hs
		808054 NEDD4_HUMAN (1-835): 0: 845: 60.41		KS6A3_HUMAN (33-474): 3.3e-108: 346: 20.04
+	Hs
		272855 NEDD4_HUMAN (1-835): 0: 845: 60.41		KS6A4_HUMAN (197-457): 5.58e-12: 71.2: 29.27
+	Hs
		272906 HECW2_HUMAN (11-833): 0: 681: 31.43		KS6A4_HUMAN (197-457): 5.58e-12: 71.2: 29.27
+	Mm
		808371 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		ARBK1_MOUSE (1-689): 0: 654: 100.00
+	Hs
		726562 SMUF1_HUMAN (94-335): 7.83e-13: 74.5: 13.06		ARBK2_HUMAN (1-685): 0: 637: 83.94
+	Hs
		568765 ITCH_HUMAN (4-322): 2.28e-12: 72.9: 14.41		KAPCA_HUMAN (152-509): 9.52e-139: 412: 28.21
+	Dm
		699453 SMUF1_DROME (6-315): 2.55e-11: 69.8: 13.07		GPRK2_DROME (144-524): 5.87e-79: 268: 41.43