HitPredict

Interactor 1: FKB1B (P68106)
Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12)
Gene: FKBP1B

Interactor 2: RYR2 (Q92736)
Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
Gene: RYR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.900

The method score is based on:

Property Details
Experiments 21262961, 12446682, 11237759, 10830164
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, pull down, competition binding, two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains EF-hand_7~FKBP_C, FKBP_C~RYDR_ITPR, FKBP_C~SPRY
Common GO terms GO:0010881 - regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016020 - membrane
GO:0030018 - Z disc
GO:0033017 - sarcoplasmic reticulum membrane
GO:0034704 - calcium channel complex
and 6 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 108
Hs

1 4967
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+ Mm
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+ Hs
+ Oc
+ Rn
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024