HitPredict

Interactor 1: ACTS (P68135)
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene: ACTA1

Interactor 2: ACTS (P68135)
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene: ACTA1

Species: Oryctolagus cuniculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 15328537, 17911258, 18591676, 19015515, 19666512, 20404198, 20625546, 20844487, 21873985, 21980262, 23027950, 24212093, 24633326, 25470062, 25533486, 26458246, 29867215, 20718862, 21499228
Identification Methods fluorescence microscopy, cosedimentation in solution, cross-linking study, 3D electron microscopy, light scattering, polymerization, classical fluorescence spectroscopy, light microscopy, transmission electron microscopy, biophysical and 1 others

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Interaction Type direct interaction, covalent binding, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Actin~Actin
Common GO terms GO:0000287 - magnesium ion binding
GO:0001725 - stress fiber
GO:0003785 - actin monomer binding
GO:0005509 - calcium ion binding
GO:0005523 - tropomyosin binding
and 23 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 377
Oc

1 377
+ At
+ Sp
+ Dm
+ Dm
+ Dm
+ Dm
+ Ce
+ Ce
+ Ce
+ Ce
+ Ce
+ Gg
+ Hs
+ Hs
+ Gg
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024