HitPredict

Interactor 1: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 448
+	Hs
		1023062 Q6LC01_HUMAN (8-443): 0: 890: 96.79		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		428177 TBB5_HUMAN (1-429): 0: 711: 98.37		MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00
+	Hs
		428041 TBB5_HUMAN (1-429): 0: 711: 98.37		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		681781 TBB4B_HUMAN (1-427): 0: 711: 100.00		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		160334 TBB5_HUMAN (1-429): 0: 711: 98.37		AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12
+	Hs
		160504 TBB4B_HUMAN (1-427): 0: 711: 100.00		AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12
+	Ce
		110167 O17921_CAEEL (1-443): 0: 710: 90.75		GCK1_CAEEL (135-444): 7.62e-111: 342: 33.02
+	Ce
		110176 TBB2_CAEEL (1-444): 0: 708: 90.32		GCK1_CAEEL (135-444): 7.62e-111: 342: 33.02
+	Hs
		933777 TBB4B_HUMAN (1-427): 0: 711: 100.00		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		428176 TBB5_HUMAN (1-429): 0: 711: 98.37		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		933780 TBB4B_HUMAN (1-427): 0: 711: 100.00		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		1026221 TBB2B_HUMAN (1-430): 0: 710: 98.14		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		734927 TBB3_HUMAN (1-443): 0: 714: 93.23		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		428055 TBB5_HUMAN (1-429): 0: 711: 98.37		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		734912 TBB4B_HUMAN (1-427): 0: 711: 100.00		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		381138 TBB4A_HUMAN (1-427): 0: 706: 98.60		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		805410 TBB3_HUMAN (1-443): 0: 714: 93.23		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		428081 TBB5_HUMAN (1-429): 0: 711: 98.37		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		805387 TBB4B_HUMAN (1-427): 0: 711: 100.00		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		805414 TBB2A_HUMAN (1-430): 0: 707: 97.67		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09