HitPredict

Interactor 1: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	10938077, 35271311
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, direct interaction, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 391 Hs			1 551
+	Hs
		586697 CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08		TF65_HUMAN (1-551): 0: 601: 100.00
+	Hs
		835681 GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12		TF65_HUMAN (1-551): 0: 601: 100.00
+	Hs
		934116 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		REL_HUMAN (12-523): 3.56e-165: 484: 41.64
+	Hs
		625382 CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74		REL_HUMAN (12-523): 3.56e-165: 484: 41.64
+	Hs
		587473 GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		835670 GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12		RELB_HUMAN (3-461): 2.62e-154: 455: 40.00
+	Hs
		835664 GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12		NFKB2_HUMAN (7-409): 7.21e-137: 420: 34.75
+	Hs
		835726 GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12		NFAC2_HUMAN (4-527): 1.26e-110: 353: 18.97
+	Hs
		317931 GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12		NFAC1_HUMAN (1-503): 2.8e-93: 307: 18.89
+	Hs
		297825 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		K0754_HUMAN (316-530): 8.16e-09: 60.7: 15.84