HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	24680668, 34079125, 36089195, 36598580, 34349018, 20452361, 12453419, 24235145, 31544921, 31485071, 29897600, 16878130, 35907431, 20541251
Identification Methods	unspecified method, proximity labelling technology, pull down, cross-linking study, enzymatic study, x-ray crystallography, isothermal titration calorimetry, nuclear magnetic resonance
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 3969
+	Hs
		975268 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		935368 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		934804 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1079993 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		935204 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		1086306 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		203659 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Hs
		935237 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV92_HUMAN (3577-3969): 7.13e-82: 278: 18.97
+	Hs
		935276 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		ASH1L_HUMAN (3266-3968): 1.46e-72: 275: 14.78
+	At
		886462 H33_ARATH (1-136): 7.67e-62: 187: 96.32		SUVH4_ARATH (3639-3968): 3.43e-77: 272: 19.90
+	Hs
		935374 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		331780 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		331823 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		935205 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		1086307 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		165661 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		935004 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		1086228 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		935150 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18
+	Hs
		152625 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47