Interactor 1: RYR2 (E9Q401)
Ryanodine receptor 2 (RYR-2) (RyR2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
Gene: RYR2

Interactor 2: FKB1B (Q9Z2I2)
Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase)
Gene: Fkbp1b

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 16481613, 22939628
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EF-hand_7~FKBP_C, FKBP_C~RYDR_ITPR, FKBP_C~SPRY
Common GO terms GO:0002027 - regulation of heart rate
GO:0010881 - regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016529 - sarcoplasmic reticulum
GO:0030018 - Z disc
GO:0033017 - sarcoplasmic reticulum membrane
and 3 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 4966
Mm

1 108
+ Hs
+ Hs
+ Hs
+ Oc
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024