HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	36598580, 23870121, 35907431
Identification Methods	pull down, unspecified method, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 4911
+	Hs
		934668 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		ANK2_HUMAN (2103-4261): 3.06e-90: 334: 11.09
+	Hs
		203659 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV91_HUMAN (4579-4910): 8.61e-90: 302: 19.18
+	Hs
		934804 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		935237 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV92_HUMAN (4579-4911): 4.38e-87: 294: 20.23
+	Hs
		331780 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Hs
		331823 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Hs
		935205 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD3_HUMAN (1-668): 2.87e-64: 246: 13.52
+	Hs
		165661 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Hs
		934770 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		1059646 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		934681 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		934705 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		975268 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		935374 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11
+	Hs
		935016 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		CHD5_HUMAN (285-390): 1.98e-22: 109: 20.16
+	Hs
		935129 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD1_HUMAN (1010-1602): 1.56e-13: 80.4: 11.26
+	Hs
		935065 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		935064 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		DPF3_HUMAN (359-435): 1.11e-11: 72: 40.00
+	Hs
		935368 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152625 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82