HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	26912663, 34079125, 36089195, 25494638, 37150325
Identification Methods	unspecified method, pull down, proximity labelling technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 2696
+	Hs
		1086280 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		203659 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV91_HUMAN (1705-2081): 6.86e-87: 293: 21.86
+	Hs
		935237 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV92_HUMAN (1702-2082): 6.86e-81: 275: 21.96
+	Hs
		331780 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		331823 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		935251 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		1086320 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		935204 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98
+	Hs
		1086306 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98
+	Hs
		935126 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		935276 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		ASH1L_HUMAN (1243-2111): 4.6e-62: 239: 17.33
+	Hs
		1086279 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		935205 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		1086307 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		934804 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		1079993 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		935004 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		1086228 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		152625 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2D_HUMAN (1011-1538): 2.41e-09: 65.8: 8.69
+	Mm
		101827 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		F8WI37_MOUSE (2088-2261): 1.86e-09: 66.2: 13.59