HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: KDM5B (Q9UGL1)
Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B)
Gene: KDM5B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.516

Property	Details
Experiments	20228790
Identification Methods	demethylase assay
Interaction Type	association, demethylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 1544
+	Hs
		1086304 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KDM5D_HUMAN (21-1484): 0: 966: 44.45
+	Hs
		782353 H32_HUMAN (1-136): 6.5e-61: 185: 99.27		KDM5C_HUMAN (21-1393): 0: 958: 47.42
+	Hs
		666522 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KDM5A_HUMAN (17-1332): 0: 951: 55.26
+	Hs
		666535 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KDM5A_HUMAN (17-1332): 0: 951: 55.26
+	Hs
		666523 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		KDM5A_HUMAN (17-1332): 0: 951: 55.26
+	Hs
		666539 H32_HUMAN (1-136): 6.5e-61: 185: 99.27		KDM5A_HUMAN (17-1332): 0: 951: 55.26
+	Hs
		301134 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KDM4B_HUMAN (339-673): 2.81e-86: 308: 26.76
+	Hs
		301136 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		KDM4B_HUMAN (339-673): 2.81e-86: 308: 26.76
+	Hs
		183098 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KDM6A_HUMAN (345-748): 7.03e-79: 289: 16.91
+	Hs
		183122 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KDM6A_HUMAN (345-748): 7.03e-79: 289: 16.91
+	Hs
		183127 H32_HUMAN (1-136): 6.5e-61: 185: 99.27		KDM6A_HUMAN (345-748): 7.03e-79: 289: 16.91
+	Hs
		935232 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KDM4C_HUMAN (339-666): 3.24e-79: 286: 26.80
+	Hs
		952622 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		KDM4C_HUMAN (339-666): 3.24e-79: 286: 26.80
+	Hs
		1174653 H32_HUMAN (1-136): 6.5e-61: 185: 99.27		KDM4C_HUMAN (339-666): 3.24e-79: 286: 26.80
+	Hs
		256961 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KDM4A_HUMAN (339-649): 2.54e-74: 272: 28.62
+	Hs
		256973 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KDM4A_HUMAN (339-649): 2.54e-74: 272: 28.62
+	Hs
		256963 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		KDM4A_HUMAN (339-649): 2.54e-74: 272: 28.62
+	Dm
		356095 H3_DROME (1-136): 6.5e-61: 185: 99.27		KDM4A_DROME (339-679): 4.8e-79: 272: 22.63
+	Mm
		952745 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		KDM6B_MOUSE (348-748): 1.62e-70: 264: 13.66
+	Hs
		165840 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KDM6B_HUMAN (348-748): 1.38e-67: 254: 13.66