HitPredict

Interactor 1: HBB (P68871)
Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]
Gene: HBB

Interactor 2: HBA (P69905)
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin]
Gene: HBA, HBA1;

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 29997244, 16169070, 32296183, 6644819, 1552945, 9830011, 9894000, unassigned1304, 9441940, 10390349, 10930828, 11724557, 15835899, 28665412, 30833564
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, two hybrid, x-ray crystallography, luminescence based mammalian interactome mapping, two hybrid array, validated two hybrid, two hybrid prey pooling approach, 3D electron microscopy, two hybrid pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Globin~Globin
Common GO terms GO:0004601 - peroxidase activity
GO:0005344 - oxygen carrier activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol
and 14 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 147
Hs

1 142
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024