HitPredict

Interactor 1: DAD3 (P69850)
DASH complex subunit DAD3 (DUO1 and DAM1-interacting protein 3) (Outer kinetochore protein DAD3)
Gene: DAD3

Interactor 2: DAD1 (Q12248)
DASH complex subunit DAD1 (DUO1 and DAM1-interacting protein 1) (Outer kinetochore protein DAD1)
Gene: DAD1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.90	0.888

The method score is based on:

Property	Details
Experiments	12925767, 17634282, 12408861, 15640796, 17460120, 37968396
Identification Methods	pull down, two hybrid, affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	DASH_Dad1~DASH_Dad3
Common GO terms	GO:0005737 - cytoplasm GO:0008608 - attachment of spindle microtubules to kinetochore GO:0031116 - positive regulation of microtubule polymerization GO:0042729 - DASH complex GO:0051010 - microtubule plus-end binding and 5 others more... GO:0051301 - cell division GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore GO:0072686 - mitotic spindle GO:1990758 - mitotic sister chromatid biorientation GO:1990976 - protein transport along microtubule to mitotic spindle pole body
Homologous interactions	0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024