HitPredict

Interactor 1: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	17389358, 14960283, 19201866
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0043122 - regulation of canonical NF-kappaB signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 530 Mm			1 442
+	Rn
		78176 TRAF6_RAT (1-530): 4.39e-142: 421: 95.85		SQSTM_RAT (1-442): 0: 762: 97.06
+	Hs
		1037028 TRAF6_HUMAN (1-530): 1.18e-143: 425: 87.93		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Rn
		70087 B1WC90_RAT (54-515): 3.39e-92: 291: 25.68		SQSTM_RAT (1-442): 0: 762: 97.06
+	Hs
		1020643 TRAF2_HUMAN (38-508): 2.54e-103: 321: 25.55		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1024670 TRAF3_HUMAN (14-510): 1.85e-90: 290: 20.94		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1023651 TRAF1_HUMAN (42-511): 3.5e-66: 221: 19.30		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		301802 TRI37_HUMAN (56-519): 8.78e-49: 183: 14.83		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1036807 TRI11_HUMAN (56-412): 3.16e-46: 169: 12.74		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1036571 TRI25_HUMAN (63-387): 4.89e-43: 164: 13.39		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		584950 RO52_HUMAN (56-417): 1.99e-43: 162: 12.88		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1019298 TRI26_HUMAN (56-437): 1.12e-40: 156: 15.08		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		536812 TRI27_HUMAN (56-385): 9.43e-39: 150: 11.87		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1036787 RN166_HUMAN (61-194): 9.33e-15: 75.7: 23.53		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1037031 RN114_HUMAN (63-232): 2.73e-11: 65.3: 19.67		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Dm
		536030 Q9W3I9_DROME (7-508): 2.26e-67: 226: 22.76		REF2P_DROME (112-173): 2.24e-18: 89.4: 41.27
+	Hs
		319958 RN166_HUMAN (61-194): 9.33e-15: 75.7: 23.53		HERC2_HUMAN (120-197): 1.35e-11: 69: 32.50