HitPredict

Interactor 1: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: MAVS (Q8VCF0)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23951545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0032481 - positive regulation of type I interferon production GO:0032755 - positive regulation of interleukin-6 production GO:0045087 - innate immune response
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 530 Mm			1 503
+	Hs
		1190136 TRAF6_HUMAN (1-530): 1.18e-143: 425: 87.93		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Mm
		761831 TRAF2_MOUSE (38-508): 8.88e-104: 322: 25.75		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Hs
		1020764 TRAF2_HUMAN (38-508): 2.54e-103: 321: 25.55		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Mm
		1141429 TRAF3_MOUSE (14-510): 9.77e-92: 293: 21.64		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Mm
		936210 TRAF5_MOUSE (43-508): 3.04e-84: 273: 24.35		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Hs
		1024700 TRAF3_HUMAN (14-510): 1.85e-90: 290: 20.94		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		129573 TRAF5_HUMAN (43-508): 2.7e-84: 273: 23.61		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1023708 TRAF1_HUMAN (42-511): 3.5e-66: 221: 19.30		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Mm
		1112453 Q3UCL2_MOUSE (60-417): 8e-43: 160: 14.01		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Hs
		1052694 TRI25_HUMAN (63-387): 4.89e-43: 164: 13.39		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		584997 RO52_HUMAN (56-417): 1.99e-43: 162: 12.88		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1190082 TRI31_HUMAN (57-384): 1.36e-41: 156: 14.71		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1190047 RN166_HUMAN (61-194): 9.33e-15: 75.7: 23.53		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1190056 RN125_HUMAN (68-194): 2.23e-11: 65.7: 26.03		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1190139 RN114_HUMAN (63-232): 2.73e-11: 65.3: 19.67		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		537122 TRI27_HUMAN (56-385): 9.43e-39: 150: 11.87		MAGL2_HUMAN (57-493): 3.47e-09: 61.7: 10.68