HitPredict

Interactor 1: SMAD1 (P70340)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
Gene: SMAD1

Interactor 2: M3K7 (Q62073)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: Map3k7

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15911626, 19536134
Identification Methods	anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000165 - MAPK cascade GO:0001649 - osteoblast differentiation GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0031625 - ubiquitin protein ligase binding GO:0060348 - bone development
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Mm			1 579
+	Mm
		956496 SMAD5_MOUSE (2-465): 0: 616: 89.03		M3K7_MOUSE (1-579): 0: 556: 100.00
+	Mm
		1143273 SMAD9_MOUSE (3-465): 0: 575: 76.51		M3K7_MOUSE (1-579): 0: 556: 100.00
+	Mm
		1143261 SMAD3_MOUSE (3-465): 0: 554: 59.44		M3K7_MOUSE (1-579): 0: 556: 100.00
+	Mm
		1143253 SMAD2_MOUSE (3-465): 0: 539: 55.14		M3K7_MOUSE (1-579): 0: 556: 100.00
+	Mm
		956544 SMAD4_MOUSE (8-454): 6.82e-151: 442: 33.33		M3K7_MOUSE (1-579): 0: 556: 100.00
+	Hs
		201132 SMAD6_HUMAN (36-443): 3.18e-93: 292: 25.61		M3K7_HUMAN (1-579): 0: 540: 94.88
+	Hs
		167311 SMAD7_HUMAN (30-131): 2.87e-25: 109: 32.46		M3K7_HUMAN (1-579): 0: 540: 94.88