HitPredict

Interactor 1: EZH1 (P70351)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Interactor 2: EED (Q921E6)
Polycomb protein EED
Gene: EED

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	20064376, 25680957
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EZH2_WD-Binding~WD40, SET~WD40
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0035098 - ESC/E(Z) complex GO:0140718 - facultative heterochromatin formation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 747 Mm			1 441
+	Hs
		268202 EZH1_HUMAN (1-747): 0: 841: 97.86		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		1142289 EZH2_MOUSE (8-746): 0: 708: 63.29		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		268116 EZH2_HUMAN (8-746): 0: 704: 63.03		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		1149787 Q6AXH7_MOUSE (8-746): 0: 684: 62.48		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Dm
		785644 EZ_DROME (8-747): 0: 692: 49.56		Q9VKD5_DROME (1-440): 2.91e-80: 257: 49.89
+	Dm
		785633 EZ_DROME (8-747): 0: 692: 49.56		Q95SW6_DROME (253-440): 2.14e-61: 199: 58.51
+	Hs
		1080207 EZH2_HUMAN (8-746): 0: 704: 63.03		FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32
+	Hs
		1080462 EZH2_HUMAN (8-746): 0: 704: 63.03		FBW1B_HUMAN (160-352): 1.57e-12: 71.3: 18.97
+	Dm
		785624 EZ_DROME (8-747): 0: 692: 49.56		ESC_DROME (23-226): 5.01e-10: 63: 8.10
+	Ce
		184559 MES2_CAEEL (109-737): 2.21e-120: 381: 23.93		MES6_CAEEL (78-440): 4.44e-85: 269: 24.13
+	Hs
		268290 EHMT1_HUMAN (419-733): 1.83e-68: 247: 23.03		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		1265660 EHMT2_MOUSE (443-733): 5.54e-68: 246: 24.16		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		268228 EHMT2_HUMAN (443-733): 2.21e-67: 244: 23.85		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Zm
		35725 A0A1D6M742_MAIZE (185-734): 3.44e-109: 349: 13.50		A0A1D6LQJ4_MAIZE (221-441): 3.05e-27: 112: 15.25
+	At
		955880 CLF_ARATH (137-734): 5.84e-108: 351: 26.26		FIE_ARATH (42-268): 3.1e-14: 75.8: 9.52
+	At
		249569 MEDEA_ARATH (356-734): 1.12e-98: 321: 33.42		FIE_ARATH (42-268): 3.1e-14: 75.8: 9.52
+	At
		1339603 EZA1_ARATH (333-734): 4.63e-95: 316: 32.32		FIE_ARATH (42-268): 3.1e-14: 75.8: 9.52
+	Hs
		1281314 EHMT2_HUMAN (443-733): 2.21e-67: 244: 23.85		FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32
+	Hs
		203735 SUV91_HUMAN (397-732): 1.58e-73: 246: 22.19		DAW1_HUMAN (292-439): 3.56e-20: 93.8: 13.91
+	Hs
		903444 EHMT2_HUMAN (443-733): 2.21e-67: 244: 23.85		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09