HitPredict

Interactor 1: UFD1 (P70362)
Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1 homolog) (UB fusion protein 1)
Gene: UFD1

Interactor 2: TERA (Q01853)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: Vcp

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

The method score is based on:

Property	Details
Experiments	10811609, 12529442, 17491009, 22232657, 22773186
Identification Methods	affinity chromatography technology, pull down, far western blotting, competition binding, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0030970 - retrograde protein transport, ER to cytosol and 7 others more... GO:0031593 - polyubiquitin modification-dependent protein binding GO:0034098 - VCP-NPL4-UFD1 AAA ATPase complex GO:0036435 - K48-linked polyubiquitin modification-dependent protein binding GO:0036503 - ERAD pathway GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044877 - protein-containing complex binding GO:0071218 - cellular response to misfolded protein
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	307
Mm

1	806

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024