HitPredict

Interactor 1: TP53B (P70399)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: Tp53bp1

Interactor 2: PAXI1 (Q6NZQ4)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: Paxip1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26744420
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006281 - DNA repair GO:0006974 - DNA damage response GO:0045830 - positive regulation of isotype switching
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1969 Mm			1 1056
+	Hs
		1018996 TP53B_HUMAN (6-1969): 0: 822: 78.69		PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47
+	Mm
		936732 TP53B_MOUSE (1-1969): 0: 924: 100.00		MDC1_MOUSE (170-1056): 2.28e-56: 216: 15.32
+	Hs
		1018956 TP53B_HUMAN (6-1969): 0: 822: 78.69		MDC1_HUMAN (143-1056): 5.13e-53: 205: 13.71
+	Hs
		1019043 TP53B_HUMAN (6-1969): 0: 822: 78.69		TOPB1_HUMAN (455-1052): 1.13e-30: 133: 13.54
+	Hs
		1019084 TP53B_HUMAN (6-1969): 0: 822: 78.69		EP400_HUMAN (239-579): 9.65e-10: 65.4: 13.80
+	Hs
		1056872 MDC1_HUMAN (2-878): 2.23e-27: 124: 8.78		PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47
+	Hs
		1056827 MDC1_HUMAN (2-878): 2.23e-27: 124: 8.78		MDC1_HUMAN (143-1056): 5.13e-53: 205: 13.71
+	Hs
		807652 MAP1B_HUMAN (34-1437): 2.21e-64: 246: 11.27		SC24C_HUMAN (150-407): 4.92e-10: 65.9: 9.67
+	Hs
		1056991 MDC1_HUMAN (2-878): 2.23e-27: 124: 8.78		ECT2_HUMAN (569-832): 1.95e-43: 173: 16.97
+	Hs
		1056907 MDC1_HUMAN (2-878): 2.23e-27: 124: 8.78		TOPB1_HUMAN (455-1052): 1.13e-30: 133: 13.54
+	Mm
		1351630 PCLO_MOUSE (131-1427): 9.29e-12: 73.1: 10.54		PCLO_MOUSE (144-831): 1.01e-37: 156: 11.89
+	Dm
		113976 M9PB30_DROME (2-608): 2.62e-16: 88.3: 9.57		M9PB30_DROME (150-859): 2.19e-14: 80.5: 8.98