HitPredict

Interactor 1: LDB1 (P70662)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (mLdb1) (Nuclear LIM interactor)
Gene: LDB1

Interactor 2: ISL2 (Q9CXV0)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0005634 - nucleus GO:0030182 - neuron differentiation GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Mm			1 359
+	Hs
		899923 LDB1_HUMAN (1-411): 0: 760: 99.76		ISL1_HUMAN (14-359): 1.15e-86: 267: 72.54
+	Mm
		899939 LDB1_MOUSE (1-411): 0: 760: 100.00		ISL1_MOUSE (14-359): 1.15e-86: 267: 72.54
+	Hs
		1199129 LDB1_HUMAN (1-411): 0: 760: 99.76		ISL2_HUMAN (1-359): 1.5e-85: 264: 98.61
+	Hs
		839771 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX2_HUMAN (24-326): 1.42e-60: 201: 27.20
+	Hs
		1199143 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX9_HUMAN (10-325): 5.96e-60: 199: 27.22
+	Mm
		899945 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX5_MOUSE (26-356): 7.29e-60: 199: 27.04
+	Hs
		822644 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX1_HUMAN (26-356): 5.2e-58: 195: 26.54
+	Mm
		925846 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX1_MOUSE (26-356): 5.67e-58: 195: 26.54
+	Hs
		903745 LDB1_HUMAN (1-411): 0: 760: 99.76		LMO4_HUMAN (15-165): 1.89e-54: 177: 38.13
+	Mm
		903798 LDB1_MOUSE (1-411): 0: 760: 100.00		LMO4_MOUSE (15-165): 1.89e-54: 177: 38.13
+	Hs
		638528 LDB1_HUMAN (1-411): 0: 760: 99.76		RBTN1_HUMAN (17-144): 5.24e-53: 174: 38.17
+	Hs
		1199126 LDB1_HUMAN (1-411): 0: 760: 99.76		LMO3_HUMAN (27-148): 1.79e-26: 104: 40.16
+	Hs
		238112 LDB1_HUMAN (1-411): 0: 760: 99.76		LMX1B_HUMAN (7-83): 9.19e-18: 85.8: 19.48
+	Mm
		291994 LDB1_MOUSE (1-411): 0: 760: 100.00		LMX1B_MOUSE (7-83): 7.55e-18: 85.8: 19.48
+	Hs
		1199128 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX4_HUMAN (1-82): 2.84e-17: 84.3: 22.89
+	Mm
		864804 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX4_MOUSE (1-82): 2.76e-17: 84.3: 22.89
+	Hs
		1199146 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX3_HUMAN (1-82): 1.39e-14: 76.2: 20.48
+	Mm
		839896 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX3_MOUSE (1-82): 6.58e-14: 74.2: 20.48
+	Hs
		1148473 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX8_HUMAN (7-82): 1.9e-13: 72.7: 19.74
+	Hs
		1199149 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX6_HUMAN (7-84): 1.63e-12: 69.6: 19.23