HitPredict

Interactor 1: F1LN91 (F1LN91)
Tensin 3
Gene: Tns3

Interactor 2: Q9QX70 (Q9QX70)
Receptor protein-tyrosine kinase (EC 2.7.10.1)
Gene: Egfr

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15140944
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0008283 - cell population proliferation GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1489 Rn			1 1209
+	Hs
		338552 TENS3_HUMAN (90-1489): 0: 746: 80.17		EGFR_HUMAN (1-1209): 0: 1227: 90.34
+	Hs
		1070975 TENS3_HUMAN (90-1489): 0: 746: 80.17		ERBB4_HUMAN (12-1198): 0: 1102: 49.38
+	Hs
		383853 TENS3_HUMAN (90-1489): 0: 746: 80.17		ERBB2_HUMAN (1-1202): 0: 1084: 48.40
+	Hs
		601935 TENS3_HUMAN (90-1489): 0: 746: 80.17		ERBB3_HUMAN (3-1151): 0: 1051: 42.43
+	Hs
		338550 TENS2_HUMAN (38-1487): 1.38e-131: 444: 32.87		EGFR_HUMAN (1-1209): 0: 1227: 90.34
+	Hs
		338213 PTEN_HUMAN (69-432): 1.52e-109: 354: 25.74		EGFR_HUMAN (1-1209): 0: 1227: 90.34
+	Hs
		1070974 TENS2_HUMAN (38-1487): 1.38e-131: 444: 32.87		ERBB4_HUMAN (12-1198): 0: 1102: 49.38
+	Hs
		383851 TENS2_HUMAN (38-1487): 1.38e-131: 444: 32.87		ERBB2_HUMAN (1-1202): 0: 1084: 48.40
+	Hs
		601934 TENS2_HUMAN (38-1487): 1.38e-131: 444: 32.87		ERBB3_HUMAN (3-1151): 0: 1051: 42.43
+	Hs
		601866 PTEN_HUMAN (69-432): 1.52e-109: 354: 25.74		ERBB3_HUMAN (3-1151): 0: 1051: 42.43
+	Hs
		601863 TPTE_HUMAN (73-385): 3.2e-97: 326: 24.85		ERBB3_HUMAN (3-1151): 0: 1051: 42.43
+	Hs
		872663 TENS3_HUMAN (90-1489): 0: 746: 80.17		EPHA4_HUMAN (661-1017): 5.12e-120: 397: 32.43
+	Rn
		94036 F1LN91_RAT (1-1489): 0: 941: 100.00		INSR_RAT (346-649): 1.29e-18: 94.4: 21.19
+	Hs
		983624 TENS3_HUMAN (90-1489): 0: 746: 80.17		FAK1_HUMAN (717-992): 2.49e-53: 206: 37.68
+	Hs
		872609 PTEN_HUMAN (69-432): 1.52e-109: 354: 25.74		EPHB1_HUMAN (634-1018): 4.17e-124: 409: 30.94
+	Hs
		665190 PTEN_HUMAN (69-432): 1.52e-109: 354: 25.74		EPHA2_HUMAN (666-1017): 7.44e-118: 391: 32.51
+	Hs
		665272 TPTE2_HUMAN (73-382): 1.77e-99: 331: 25.37		EPHA2_HUMAN (666-1017): 7.44e-118: 391: 32.51
+	Hs
		665187 TPTE_HUMAN (73-385): 3.2e-97: 326: 24.85		EPHA2_HUMAN (666-1017): 7.44e-118: 391: 32.51
+	Hs
		161650 GAK_HUMAN (66-844): 5.57e-102: 358: 16.40		ACK1_HUMAN (692-968): 2.35e-55: 212: 39.58
+	Hs
		890623 PTEN_HUMAN (69-432): 1.52e-109: 354: 25.74		FAK1_HUMAN (717-992): 2.49e-53: 206: 37.68