HitPredict

Interactor 1: CXAR (P78310)
Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)
Gene: CXADR

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2-set_2~Ig_3, Ig_3~V-set, C2-set_2~V-set, V-set~V-set
Common GO terms	GO:0001618 - virus receptor activity GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0050839 - cell adhesion molecule binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 538
+	Hs
		1061308 OPCM_HUMAN (1-311): 1.47e-51: 176: 17.45		NTRI_HUMAN (20-360): 4.8e-54: 187: 15.58
+	Hs
		1349888 NTRI_HUMAN (1-312): 4.68e-50: 172: 18.94		NTRI_HUMAN (20-360): 4.8e-54: 187: 15.58
+	Hs
		1188165 NEGR1_HUMAN (27-318): 5.18e-44: 157: 16.56		NTRI_HUMAN (20-360): 4.8e-54: 187: 15.58
+	Hs
		940526 CXAR_HUMAN (1-365): 5.66e-82: 256: 100.00		KIRR1_HUMAN (33-363): 7.38e-16: 82.9: 16.72
+	Hs
		530171 OPCM_HUMAN (1-311): 1.47e-51: 176: 17.45		NCAM1_HUMAN (33-529): 2.22e-37: 149: 13.30
+	Ce
		103933 SAX3_CAEEL (11-341): 5.51e-33: 132: 12.54		SAX3_CAEEL (33-444): 1.01e-47: 180: 13.54
+	Hs
		1336275 ROBO2_HUMAN (1-364): 3.87e-45: 167: 13.58		ROBO1_HUMAN (333-538): 1.79e-18: 91.7: 8.92
+	Dm
		219801 O44924_DROME (10-361): 2.41e-46: 171: 13.86		O44924_DROME (347-538): 1.1e-16: 85.9: 9.27
+	Hs
		299578 LRIG2_HUMAN (140-365): 7.8e-27: 114: 13.25		LRIG1_HUMAN (153-427): 4.08e-34: 139: 14.14
+	Hs
		1166661 LRIG3_HUMAN (138-365): 2.08e-26: 112: 13.20		LRIG1_HUMAN (153-427): 4.08e-34: 139: 14.14
+	Hs
		1336269 ROBO2_HUMAN (1-364): 3.87e-45: 167: 13.58		ROBO2_HUMAN (449-538): 4.89e-11: 67.8: 15.15
+	Hs
		1378225 ROBO1_HUMAN (11-345): 1.8e-35: 139: 14.00		ROBO1_HUMAN (333-538): 1.79e-18: 91.7: 8.92
+	Rn
		222935 DCC_RAT (1-365): 1.46e-37: 145: 12.88		ROBO1_RAT (449-538): 3.55e-10: 65.1: 14.14
+	Dm
		1372240 Q9VQ08_DROME (11-335): 1.41e-23: 104: 10.54		Q9VQ08_DROME (348-538): 5.69e-20: 96.3: 10.26
+	Hs
		1264775 NEO1_HUMAN (20-365): 3.15e-28: 118: 13.86		TITIN_HUMAN (171-517): 2.2e-09: 62.8: 13.49
+	Dm
		1325660 Q9GPP6_DROME (12-334): 2.54e-21: 97.7: 11.54		Q9GPP6_DROME (24-365): 1.04e-15: 82.9: 9.24
+	Dm
		1372236 Q9VPZ7_DROME (12-334): 2.45e-21: 97.7: 11.54		Q9VPZ7_DROME (24-365): 9.53e-16: 82.9: 9.24
+	Hs
		68238 HECA2_HUMAN (13-254): 1.21e-23: 103: 20.00		CADM4_HUMAN (267-538): 2.9e-12: 70.5: 11.03