HitPredict

Interactor 1: 3BP2 (P78314)
SH3 domain-binding protein 2 (3BP-2)
Gene: SH3BP2

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.832

Property	Details
Experiments	17306257, 19531213
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0017124 - SH3 domain binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 561 Hs			1 665
+	Hs
		203241 SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		924462 3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		1186102 MICA3_HUMAN (161-510): 2.13e-25: 113: 14.77		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		548682 3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		940670 3BP2_HUMAN (1-561): 7.83e-99: 312: 100.00		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Hs
		203208 SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		203218 SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		554292 MUC1_HUMAN (147-560): 2.58e-13: 75.2: 10.05		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		924760 PRG4_HUMAN (69-521): 1.59e-10: 66.4: 9.75		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		517796 NFH_HUMAN (95-479): 5.25e-09: 61.2: 13.04		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		203228 SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Rn
		192744 SYNJ1_RAT (72-534): 1.53e-18: 92.2: 12.84		SRBS2_RAT (3-155): 3.11e-11: 68.9: 30.25
+	Hs
		203191 SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		203192 SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Hs
		203230 SYNJ1_HUMAN (77-549): 4.24e-14: 77.9: 11.48		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31