HitPredict

Interactor 1: RNF4 (P78317)
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)
Gene: RNF4

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 190 Hs			1 624
+	Hs
		941579 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		1292361 RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1292364 RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Xl
		1140127 Q5XGX4_XENLA (103-189): 1.43e-21: 88.6: 23.33		Q6DCM1_XENLA (32-624): 2e-134: 406: 67.34
+	Xl
		1140144 Q5XGX4_XENLA (103-189): 1.43e-21: 88.6: 23.33		Q801P8_XENLA (14-624): 5.36e-133: 404: 55.26
+	Hs
		1292358 RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	At
		1352315 PEX10_ARATH (56-189): 1.19e-23: 97.8: 17.78		DSK2B_ARATH (15-544): 6.1e-93: 298: 28.13
+	At
		1352316 PEX10_ARATH (56-189): 1.19e-23: 97.8: 17.78		DSK2A_ARATH (15-544): 4.66e-86: 280: 27.56
+	Hs
		803484 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		941084 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		TMUB2_HUMAN (6-143): 8.33e-26: 110: 25.00
+	Hs
		584896 RO52_HUMAN (120-187): 1.12e-11: 64.3: 34.78		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Xl
		1140133 Q5XGX4_XENLA (103-189): 1.43e-21: 88.6: 23.33		Q6GQF3_XENLA (33-112): 7.49e-34: 127: 30.86
+	Dm
		574857 Q9VJB0_DROME (99-190): 2e-21: 89.3: 26.09		RL40_DROME (33-112): 3.08e-31: 120: 30.86
+	Hs
		1174918 RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34		TMUB2_HUMAN (6-143): 8.33e-26: 110: 25.00
+	Xl
		1140130 Q5XGX4_XENLA (103-189): 1.43e-21: 88.6: 23.33		Q6GMC1_XENLA (33-119): 4.49e-24: 100: 27.27
+	Hs
		924117 RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Dm
		547949 Q9VJB0_DROME (99-190): 2e-21: 89.3: 26.09		RS27A_DROME (33-103): 6.99e-13: 68.4: 33.33