HitPredict

Interactor 1: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Interactor 2: NEK1 (Q96PY6)
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)
Gene: NEK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	19299420
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~V-set
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 1258
+	Hs
		681784 SHPS1_HUMAN (1-504): 4.62e-114: 348: 100.00		AKT1_HUMAN (1-316): 5.31e-119: 380: 27.41
+	Hs
		149131 PXDN_HUMAN (228-487): 3.51e-25: 112: 14.23		CTRO_HUMAN (2-1006): 2.42e-143: 481: 16.04
+	Rn
		530226 NCAM1_RAT (241-498): 1.9e-16: 84.4: 10.43		ROCK1_RAT (2-1044): 5.48e-144: 473: 15.64
+	Hs
		1039068 MYLK_HUMAN (231-481): 5.31e-12: 70.9: 9.66		KCC2D_HUMAN (2-281): 1.99e-112: 363: 28.82
+	Hs
		851633 KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68		NEK4_HUMAN (1-266): 1.31e-78: 279: 50.56
+	Hs
		1254357 TITIN_HUMAN (43-445): 2.05e-11: 69: 11.20		NEK9_HUMAN (4-261): 3.69e-61: 229: 42.31
+	Hs
		1071679 KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68		KS6A2_HUMAN (8-274): 4.38e-19: 95.5: 25.45