HitPredict

Interactor 1: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Interactor 2: TRIM2 (Q9C040)
Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)
Gene: TRIM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.50	0.599

Property	Details
Experiments	25416956, 16189514, 32296183
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 744
+	Hs
		536783 SHPS1_HUMAN (1-504): 4.62e-114: 348: 100.00		TRI27_HUMAN (8-509): 4.56e-84: 277: 13.11
+	Ce
		136810 UNC89_CAEEL (158-493): 2.63e-16: 84.8: 11.99		LIN41_CAEEL (1-740): 1.37e-103: 345: 20.80
+	Hs
		734591 SHPS1_HUMAN (1-504): 4.62e-114: 348: 100.00		TRI23_HUMAN (19-172): 3.16e-15: 81.3: 30.72
+	Hs
		242896 ROBO2_HUMAN (24-494): 2.34e-25: 112: 11.56		TRI13_HUMAN (15-309): 1.69e-55: 197: 21.59
+	Hs
		1264780 TITIN_HUMAN (43-445): 2.05e-11: 69: 11.20		TRI63_HUMAN (13-283): 2.14e-62: 214: 21.95
+	Hs
		1264796 TITIN_HUMAN (43-445): 2.05e-11: 69: 11.20		TRI54_HUMAN (13-317): 1.92e-59: 206: 21.78
+	Hs
		1264797 TITIN_HUMAN (43-445): 2.05e-11: 69: 11.20		TRI55_HUMAN (16-220): 7.46e-15: 80.1: 27.23