HitPredict

Interactor 1: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Interactor 2: CLC4A (Q9UMR7)
C-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367)
Gene: CLEC4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0032720 - negative regulation of tumor necrosis factor production
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 237
+	Hs
		1245267 CADM4_HUMAN (38-426): 3.78e-56: 194: 16.92		CLC4A_HUMAN (1-237): 9.8e-70: 215: 100.00
+	Hs
		1045068 CD166_HUMAN (1-312): 3.34e-54: 193: 18.62		CLC4A_HUMAN (1-237): 9.8e-70: 215: 100.00
+	Hs
		1357318 ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25		CLC4A_HUMAN (1-237): 9.8e-70: 215: 100.00
+	Hs
		1268547 PXDN_HUMAN (228-487): 3.51e-25: 112: 14.23		CLC4A_HUMAN (1-237): 9.8e-70: 215: 100.00
+	Hs
		1294928 KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68		CLC4A_HUMAN (1-237): 9.8e-70: 215: 100.00