HitPredict

Interactor 1: ADAM8 (P78325)
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a)
Gene: ADAM8

Interactor 2: SNX33 (Q8WV41)
Sorting nexin-33 (SH3 and PX domain-containing protein 3)
Gene: SNX33

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25825872
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051044 - positive regulation of membrane protein ectodomain proteolysis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 824 Hs			1 574
+	Hs
		941718 ADAM8_HUMAN (1-824): 0: 633: 100.00		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		941716 ADAM8_HUMAN (1-824): 0: 633: 100.00		SNX18_HUMAN (1-491): 9.22e-118: 363: 45.84
+	Hs
		1034713 ADAM9_HUMAN (24-723): 4.42e-157: 480: 30.77		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		197615 ADA12_HUMAN (23-824): 7.76e-150: 464: 34.24		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		1261046 ADA19_HUMAN (28-824): 2.25e-144: 451: 33.07		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		1034745 ADAM9_HUMAN (24-723): 4.42e-157: 480: 30.77		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		197626 ADA12_HUMAN (23-824): 7.76e-150: 464: 34.24		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		1327036 ADA19_HUMAN (28-824): 2.25e-144: 451: 33.07		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		1034764 ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		1034718 ADAM9_HUMAN (24-723): 4.42e-157: 480: 30.77		SNX18_HUMAN (1-491): 9.22e-118: 363: 45.84
+	Hs
		1034782 ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		1300856 ATS1_HUMAN (51-628): 1.06e-99: 333: 22.42		SNX18_HUMAN (1-491): 9.22e-118: 363: 45.84
+	Hs
		1034755 ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82		SNX30_HUMAN (143-573): 2.52e-67: 226: 18.79
+	Hs
		152313 ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		944513 ADA17_HUMAN (106-530): 1.19e-20: 99.8: 25.45		SNX33_HUMAN (1-574): 2.44e-156: 461: 100.00
+	Hs
		152355 ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		944533 ADA17_HUMAN (106-530): 1.19e-20: 99.8: 25.45		SNX9_HUMAN (1-571): 1.57e-139: 419: 34.18
+	Hs
		152323 ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91		SNX18_HUMAN (1-491): 9.22e-118: 363: 45.84
+	Hs
		944518 ADA17_HUMAN (106-530): 1.19e-20: 99.8: 25.45		SNX18_HUMAN (1-491): 9.22e-118: 363: 45.84
+	Hs
		152211 ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91		GAS7_HUMAN (2-478): 1.98e-54: 193: 13.21