HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	12713445, 10827173
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 4655
+	Mm
		57555 DLG4_MOUSE (1-724): 0: 667: 99.59		LRP2_MOUSE (22-4655): 0: 3723: 76.66
+	Hs
		957608 DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		957631 DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		942339 DLG4_HUMAN (1-724): 0: 667: 100.00		LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92
+	Mm
		1143476 DLG4_MOUSE (1-724): 0: 667: 99.59		LRP8_MOUSE (2623-2869): 2.33e-11: 72.6: 16.36
+	Mm
		69882 DLG4_MOUSE (1-724): 0: 667: 99.59		B1AXJ3_MOUSE (3424-3628): 4.43e-11: 71.8: 12.50
+	Mm
		1143471 DLG4_MOUSE (1-724): 0: 667: 99.59		LRP1_MOUSE (3672-3974): 3.08e-09: 66: 10.16
+	Hs
		942331 DLG4_HUMAN (1-724): 0: 667: 100.00		LRP1_HUMAN (1102-1387): 4.45e-09: 65.6: 13.59