HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: EM55 (Q00013)
55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)
Gene: MPP1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_1, PDZ~PDZ, SH3_1~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030863 - cortical cytoskeleton
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 466
+	Mm
		1143555 DLG4_MOUSE (1-724): 0: 667: 99.59		MPP2_MOUSE (12-466): 1.05e-132: 396: 37.08
+	Hs
		159190 DLG4_HUMAN (1-724): 0: 667: 100.00		CSKP_HUMAN (6-466): 3.61e-126: 390: 49.11
+	Mm
		1143321 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG4_MOUSE (14-163): 3.15e-20: 95.7: 12.74
+	Mm
		1143467 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG2_MOUSE (18-152): 4.19e-20: 95.7: 18.31
+	Hs
		942349 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG2_HUMAN (18-152): 6.52e-20: 94.9: 18.31
+	Hs
		942321 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG4_HUMAN (60-182): 6.95e-20: 94.6: 22.31
+	Mm
		1113136 DLG4_MOUSE (1-724): 0: 667: 99.59		Q3UP61_MOUSE (62-217): 7.57e-18: 88.4: 18.45
+	Mm
		1143387 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG1_MOUSE (62-217): 1.44e-17: 87.6: 18.45
+	Rn
		677787 DLG4_RAT (1-724): 0: 668: 99.86		DLG1_RAT (70-217): 2.21e-16: 84.2: 18.13
+	Rn
		677790 DLG4_RAT (1-724): 0: 668: 99.86		DLG3_RAT (27-141): 6.64e-15: 79.2: 18.94
+	Mm
		936180 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG3_MOUSE (43-141): 8.73e-15: 79.2: 20.00
+	Mm
		1119795 DLG4_MOUSE (1-724): 0: 667: 99.59		Q52KF7_MOUSE (71-141): 3.36e-14: 77.2: 20.51
+	Hs
		942364 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG3_HUMAN (71-141): 3.36e-14: 77.2: 20.51
+	Mm
		936188 DLG3_MOUSE (20-724): 0: 583: 64.08		DLG2_MOUSE (18-152): 4.19e-20: 95.7: 18.31
+	Hs
		1232493 MPP4_HUMAN (1-279): 6.81e-23: 105: 13.73		PALS1_HUMAN (5-465): 9.92e-121: 369: 28.20
+	Hs
		1295085 MPP4_HUMAN (1-279): 6.81e-23: 105: 13.73		MPP4_HUMAN (9-465): 3.02e-120: 366: 26.48
+	Rn
		292499 MPP3_RAT (225-719): 4.92e-117: 365: 22.42		DLG1_RAT (70-217): 2.21e-16: 84.2: 18.13
+	Hs
		1021489 MPP2_HUMAN (2-383): 6.03e-22: 102: 14.54		DLG1_HUMAN (62-217): 1.93e-17: 87.2: 17.86