HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: FRPD4 (Q14CM0)
FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso)
Gene: FRMPD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30126976
Identification Methods	p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0043197 - dendritic spine
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 1322
+	Mm
		57065 DLG4_MOUSE (1-724): 0: 667: 99.59		FRPD4_MOUSE (1-1322): 0: 2167: 90.70
+	Hs
		1049949 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		FRPD4_HUMAN (1-1322): 0: 2166: 100.00
+	Hs
		1021493 DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93		FRPD4_HUMAN (1-1322): 0: 2166: 100.00
+	Hs
		1062034 DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58		FRPD4_HUMAN (1-1322): 0: 2166: 100.00
+	Mm
		710140 DLG4_MOUSE (1-724): 0: 667: 99.59		FAK1_MOUSE (202-540): 1.15e-68: 253: 23.18
+	Hs
		942340 DLG4_HUMAN (1-724): 0: 667: 100.00		FAK2_HUMAN (191-539): 1.73e-66: 246: 20.87
+	Mm
		3560 DLG4_MOUSE (1-724): 0: 667: 99.59		A0A140LIW3_MOUSE (776-940): 1.25e-63: 241: 47.65
+	Mm
		1143518 DLG4_MOUSE (1-724): 0: 667: 99.59		MAGI3_MOUSE (14-161): 3.18e-39: 161: 23.94
+	Mm
		1143406 DLG4_MOUSE (1-724): 0: 667: 99.59		Q8BXG0_MOUSE (193-312): 2.25e-41: 150: 56.67
+	Hs
		1049972 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		FRPD1_HUMAN (62-539): 1.99e-144: 480: 49.38
+	Hs
		1052831 DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58		FAK2_HUMAN (191-539): 1.73e-66: 246: 20.87
+	Hs
		1232496 PALS1_HUMAN (3-238): 7.09e-18: 90.2: 12.30		MAGI1_HUMAN (14-158): 1.21e-25: 117: 17.50