HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: GRIK5 (Q16478)
Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)
Gene: GRIK5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	11279111, 9808460
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0098839 - postsynaptic density membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 980
+	Mm
		1142982 DLG4_MOUSE (1-724): 0: 667: 99.59		GRIK5_MOUSE (1-980): 0: 892: 98.27
+	Rn
		677766 DLG4_RAT (1-724): 0: 668: 99.86		GRIK2_RAT (5-892): 0: 861: 43.65
+	Hs
		942335 DLG4_HUMAN (1-724): 0: 667: 100.00		GRIK2_HUMAN (7-892): 0: 862: 43.86
+	Mm
		761217 DLG4_MOUSE (1-724): 0: 667: 99.59		GRIK2_MOUSE (5-892): 0: 861: 43.65
+	Hs
		761199 DLG4_HUMAN (1-724): 0: 667: 100.00		GRIK1_HUMAN (5-838): 0: 841: 43.71
+	Rn
		585138 DLG4_RAT (1-724): 0: 668: 99.86		GRIA1_RAT (1-902): 0: 788: 33.77
+	Mm
		620892 DLG4_MOUSE (1-724): 0: 667: 99.59		GRIA1_MOUSE (1-902): 0: 786: 33.77
+	Hs
		786757 DLG4_HUMAN (1-724): 0: 667: 100.00		GRIA3_HUMAN (5-847): 0: 771: 35.07
+	Mm
		1143565 DLG4_MOUSE (1-724): 0: 667: 99.59		GRIA4_MOUSE (4-878): 0: 770: 33.48
+	Mm
		1143566 DLG4_MOUSE (1-724): 0: 667: 99.59		GRIA3_MOUSE (5-847): 0: 770: 35.07
+	Hs
		786726 DLG4_HUMAN (1-724): 0: 667: 100.00		GRIA2_HUMAN (6-847): 0: 753: 34.61
+	Mm
		620965 DLG4_MOUSE (1-724): 0: 667: 99.59		GRIA2_MOUSE (6-847): 0: 748: 34.49
+	Mm
		1142961 DLG4_MOUSE (1-724): 0: 667: 99.59		GRID2_MOUSE (3-971): 0: 661: 22.46
+	Rn
		677792 DLG4_RAT (1-724): 0: 668: 99.86		GRID2_RAT (2-971): 0: 657: 22.29
+	Mm
		963785 DLG4_MOUSE (1-724): 0: 667: 99.59		NMDE3_MOUSE (2-979): 0: 640: 19.33
+	Mm
		1142983 DLG4_MOUSE (1-724): 0: 667: 99.59		GRID1_MOUSE (5-972): 0: 634: 24.10
+	Rn
		677765 DLG4_RAT (1-724): 0: 668: 99.86		NMDZ1_RAT (5-916): 0: 629: 23.23
+	Mm
		723586 DLG4_MOUSE (1-724): 0: 667: 99.59		NMDZ1_MOUSE (5-916): 0: 628: 23.43
+	Hs
		942329 DLG4_HUMAN (1-724): 0: 667: 100.00		NMDZ1_HUMAN (5-916): 0: 626: 23.12
+	Mm
		57144 DLG4_MOUSE (1-724): 0: 667: 99.59		A2AI21_MOUSE (5-916): 0: 621: 23.04