HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10341223
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0016323 - basolateral plasma membrane GO:0030165 - PDZ domain binding GO:0045202 - synapse GO:0098839 - postsynaptic density membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 207
+	Rn
		677810 DLG4_RAT (1-724): 0: 668: 99.86		LIN7B_RAT (1-207): 2.14e-63: 196: 98.55
+	Hs
		942387 DLG4_HUMAN (1-724): 0: 667: 100.00		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		158271 DLG4_HUMAN (1-724): 0: 667: 100.00		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		159190 DLG4_HUMAN (1-724): 0: 667: 100.00		CSKP_HUMAN (10-206): 4.77e-31: 121: 20.00
+	Mm
		1113136 DLG4_MOUSE (1-724): 0: 667: 99.59		Q3UP61_MOUSE (23-181): 9.78e-26: 105: 25.00
+	Mm
		1143467 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG2_MOUSE (89-202): 4.39e-25: 104: 29.41
+	Rn
		677787 DLG4_RAT (1-724): 0: 668: 99.86		DLG1_RAT (57-191): 8.24e-25: 103: 25.71
+	Hs
		942349 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG2_HUMAN (89-202): 4.85e-25: 103: 29.41
+	Mm
		1143321 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Hs
		942321 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG4_HUMAN (86-206): 6.05e-24: 100: 27.78
+	Mm
		1143387 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG1_MOUSE (67-191): 1.67e-22: 96.7: 29.77
+	Rn
		677790 DLG4_RAT (1-724): 0: 668: 99.86		DLG3_RAT (59-164): 2.5e-21: 93: 31.53
+	Mm
		936180 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG3_MOUSE (59-164): 2.62e-21: 93: 31.53
+	Hs
		942364 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG3_HUMAN (29-164): 2.29e-20: 90.3: 25.53
+	Mm
		1119795 DLG4_MOUSE (1-724): 0: 667: 99.59		Q52KF7_MOUSE (29-164): 3.8e-20: 89.9: 24.82
+	Mm
		1112558 DLG4_MOUSE (1-724): 0: 667: 99.59		SNX27_MOUSE (91-175): 2.78e-13: 69.7: 39.18
+	Mm
		936188 DLG3_MOUSE (20-724): 0: 583: 64.08		DLG2_MOUSE (89-202): 4.39e-25: 104: 29.41
+	Ce
		873636 LIN2_CAEEL (80-719): 2.76e-103: 340: 20.21		Q9U245_CAEEL (9-206): 5.71e-47: 155: 65.66
+	Rn
		292499 MPP3_RAT (225-719): 4.92e-117: 365: 22.42		DLG1_RAT (57-191): 8.24e-25: 103: 25.71