HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016323 - basolateral plasma membrane GO:0045202 - synapse GO:0098839 - postsynaptic density membrane and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 197
+	Rn
		677810 DLG4_RAT (1-724): 0: 668: 99.86		LIN7B_RAT (1-196): 7.76e-55: 174: 85.71
+	Hs
		942382 DLG4_HUMAN (1-724): 0: 667: 100.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		158271 DLG4_HUMAN (1-724): 0: 667: 100.00		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		159190 DLG4_HUMAN (1-724): 0: 667: 100.00		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Mm
		1143467 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG2_MOUSE (23-196): 1.12e-25: 105: 23.63
+	Hs
		942349 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG2_HUMAN (23-196): 1.68e-25: 104: 23.63
+	Mm
		1143321 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Mm
		1113136 DLG4_MOUSE (1-724): 0: 667: 99.59		Q3UP61_MOUSE (23-178): 1.97e-23: 98.7: 26.09
+	Hs
		942321 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Mm
		1143387 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG1_MOUSE (50-178): 1.33e-22: 96.3: 30.60
+	Rn
		677787 DLG4_RAT (1-724): 0: 668: 99.86		DLG1_RAT (94-178): 2.77e-21: 92.5: 37.78
+	Rn
		677790 DLG4_RAT (1-724): 0: 668: 99.86		DLG3_RAT (60-164): 3.16e-21: 92.5: 32.73
+	Mm
		936180 DLG4_MOUSE (1-724): 0: 667: 99.59		DLG3_MOUSE (60-164): 3.31e-21: 92.5: 32.73
+	Mm
		1119795 DLG4_MOUSE (1-724): 0: 667: 99.59		Q52KF7_MOUSE (74-164): 2.82e-20: 89.8: 35.42
+	Hs
		942364 DLG4_HUMAN (1-724): 0: 667: 100.00		DLG3_HUMAN (74-164): 2.8e-20: 89.8: 35.42
+	Mm
		1112558 DLG4_MOUSE (1-724): 0: 667: 99.59		SNX27_MOUSE (91-175): 2.32e-13: 69.7: 39.18
+	Mm
		936188 DLG3_MOUSE (20-724): 0: 583: 64.08		DLG2_MOUSE (23-196): 1.12e-25: 105: 23.63
+	Ce
		873636 LIN2_CAEEL (80-719): 2.76e-103: 340: 20.21		Q9U245_CAEEL (3-195): 2.33e-42: 142: 67.88
+	Rn
		292499 MPP3_RAT (225-719): 4.92e-117: 365: 22.42		DLG1_RAT (94-178): 2.77e-21: 92.5: 37.78