HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: KCND2 (Q9NZV8)
Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)
Gene: KCND2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	12435606
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0043197 - dendritic spine GO:0045211 - postsynaptic membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 630
+	Hs
		942333 DLG4_HUMAN (1-724): 0: 667: 100.00		KCNA1_HUMAN (5-425): 6.56e-131: 395: 34.31
+	Mm
		558703 DLG4_MOUSE (1-724): 0: 667: 99.59		KCNA1_MOUSE (5-425): 7.19e-130: 392: 34.09
+	Mm
		927733 DLG4_MOUSE (1-724): 0: 667: 99.59		KCNA2_MOUSE (5-497): 9.71e-130: 392: 32.25
+	Hs
		558713 DLG4_HUMAN (1-724): 0: 667: 100.00		KCNA2_HUMAN (5-497): 4.44e-129: 390: 32.25
+	Hs
		608268 DLG4_HUMAN (1-724): 0: 667: 100.00		KCNA5_HUMAN (33-492): 2.06e-123: 380: 30.56
+	Hs
		608221 DLG4_HUMAN (1-724): 0: 667: 100.00		KCNA4_HUMAN (35-478): 7.81e-122: 377: 30.72
+	Rn
		548174 DLG4_RAT (1-724): 0: 668: 99.86		KCNA4_RAT (35-478): 1.08e-120: 374: 30.72
+	Mm
		1142574 DLG4_MOUSE (1-724): 0: 667: 99.59		KCNA4_MOUSE (35-490): 1.87e-120: 373: 31.22
+	Mm
		558878 DLG4_MOUSE (1-724): 0: 667: 99.59		KCNA3_MOUSE (28-424): 8.54e-121: 370: 36.30
+	Hs
		602901 DLG4_HUMAN (1-724): 0: 667: 100.00		KCNA3_HUMAN (28-424): 4.38e-120: 370: 36.07
+	Mm
		1143189 DLG4_MOUSE (1-724): 0: 667: 99.59		KCNA6_MOUSE (29-422): 1.01e-110: 344: 33.12
+	Hs
		1050021 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		KCNB2_HUMAN (25-581): 3.68e-143: 440: 30.28
+	Hs
		608277 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		KCNA5_HUMAN (33-492): 2.06e-123: 380: 30.56
+	Hs
		608230 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		KCNA4_HUMAN (35-478): 7.81e-122: 377: 30.72
+	Rn
		580271 DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97		KCNA5_RAT (6-492): 2.85e-128: 392: 30.90
+	Hs
		608222 EM55_HUMAN (2-325): 2.03e-22: 103: 14.41		KCNA4_HUMAN (35-478): 7.81e-122: 377: 30.72
+	Rn
		626888 DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97		KCNC1_RAT (34-530): 9.09e-125: 382: 28.93
+	Hs
		608224 DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93		KCNA4_HUMAN (35-478): 7.81e-122: 377: 30.72
+	Hs
		608232 MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50		KCNA4_HUMAN (35-478): 7.81e-122: 377: 30.72
+	Hs
		602905 DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93		KCNA3_HUMAN (28-424): 4.38e-120: 370: 36.07