HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: PURA (Q00577)
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)
Gene: PURA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 688 Hs			1 322
+	Hs
		942885 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		PURB_HUMAN (52-290): 5.82e-111: 326: 72.29
+	Hs
		943010 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		PURG_HUMAN (51-301): 2.2e-105: 313: 53.22
+	Hs
		1302092 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		PURG_HUMAN (51-301): 2.2e-105: 313: 53.22
+	Hs
		960589 SRPK3_HUMAN (450-687): 1.19e-63: 223: 66.39		PURA_HUMAN (1-322): 1.72e-144: 411: 100.00
+	Hs
		960547 DYRK2_HUMAN (51-234): 1.48e-62: 221: 29.35		PURA_HUMAN (1-322): 1.72e-144: 411: 100.00
+	Hs
		833988 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		PURG_HUMAN (51-301): 2.2e-105: 313: 53.22
+	Hs
		834141 CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11		PURG_HUMAN (51-301): 2.2e-105: 313: 53.22
+	Hs
		1047644 CDK13_HUMAN (373-687): 1.6e-54: 204: 15.85		PURG_HUMAN (51-301): 2.2e-105: 313: 53.22
+	Hs
		1348694 CDK12_HUMAN (291-687): 5.8e-54: 203: 13.17		PURG_HUMAN (51-301): 2.2e-105: 313: 53.22
+	Zm
		11277 A0A1D6G8W8_MAIZE (63-222): 1.48e-46: 178: 31.52		A0A1D6FBT4_MAIZE (191-280): 8.36e-31: 121: 29.31