HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33742100
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 688 Hs			1 2414
+	Hs
		998998 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		625393 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		270406 KS6A5_HUMAN (3-343): 1.04e-72: 252: 14.52		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		999248 DYR1B_HUMAN (502-686): 8.03e-59: 211: 28.02		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		999150 CDK12_HUMAN (291-687): 5.8e-54: 203: 13.17		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		942975 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31
+	Hs
		942673 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		942660 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		1356278 KS6A6_HUMAN (2-362): 5.53e-77: 263: 15.92		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Sp
		737010 DSK1_SCHPO (437-686): 7.4e-74: 250: 44.40		YK82_SCHPO (990-1155): 2.19e-28: 126: 20.48
+	Hs
		625532 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		1057021 KS6A6_HUMAN (2-362): 5.53e-77: 263: 15.92		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		850689 KS6A3_HUMAN (2-362): 2.51e-78: 266: 13.83		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Mm
		101422 KS6A3_MOUSE (2-362): 2.34e-78: 266: 13.83		F8VPR5_MOUSE (1752-2401): 7.8e-10: 67.1: 12.31
+	Hs
		1071667 KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		1073459 KS6A1_HUMAN (2-359): 1.19e-76: 262: 14.13		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		270431 KS6A5_HUMAN (3-343): 1.04e-72: 252: 14.52		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		1270845 DYR1B_HUMAN (502-686): 8.03e-59: 211: 28.02		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Sc
		419948 SNF1_YEAST (380-687): 4.14e-43: 166: 11.90		GCN5_YEAST (1074-1156): 2.55e-12: 73.6: 38.55
+	Sc
		419974 SNF1_YEAST (380-687): 4.14e-43: 166: 11.90		BDF2_YEAST (1072-1149): 1.81e-11: 71.6: 44.87