HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: ZCC17 (Q9NP64)
Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein)
Gene: ZCCHC17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	26167880
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~S1
Common GO terms	GO:0003723 - RNA binding GO:0005730 - nucleolus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 688 Hs			1 241
+	Hs
		942655 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		DHX8_HUMAN (1-241): 2.29e-31: 123: 18.07
+	Hs
		1055458 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		DHX8_HUMAN (1-241): 2.29e-31: 123: 18.07
+	Hs
		942663 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		RRP5_HUMAN (1-89): 2.06e-16: 80: 23.60
+	Hs
		1058010 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		RRP5_HUMAN (1-89): 2.06e-16: 80: 23.60
+	Sp
		193837 DSK1_SCHPO (437-686): 7.4e-74: 250: 44.40		PRP22_SCHPO (9-189): 7.58e-35: 133: 29.47
+	Sp
		193840 LKH1_SCHPO (492-687): 1.24e-59: 214: 24.63		PRP22_SCHPO (9-189): 7.58e-35: 133: 29.47
+	Hs
		1047592 CDK13_HUMAN (373-687): 1.6e-54: 204: 15.85		DHX8_HUMAN (1-241): 2.29e-31: 123: 18.07
+	Hs
		1055492 CDK12_HUMAN (291-687): 5.8e-54: 203: 13.17		DHX8_HUMAN (1-241): 2.29e-31: 123: 18.07
+	Hs
		1058069 SRPK3_HUMAN (450-687): 1.19e-63: 223: 66.39		RRP5_HUMAN (1-89): 2.06e-16: 80: 23.60
+	Hs
		834043 CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11		RRP5_HUMAN (1-89): 2.06e-16: 80: 23.60