HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: DDX21 (Q9NR30)
Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)
Gene: DDX21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.78 0.60 0.688

The method score is based on:

Property Details
Experiments 33961781, 26167880, 23602568
Identification Methods affinity chromatography technology, enzymatic study, fluorescent resonance energy transfer, tandem affinity purification, anti tag coimmunoprecipitation, bimolecular fluorescence complementation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005829 - cytosol
and 2 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 688
Hs

1 783
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs
+ Hs
+ Zm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024