HitPredict

Interactor 1: PHC1 (P78364)
Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)
Gene: PHC1

Interactor 2: CBX2 (Q14781)
Chromobox protein homolog 2
Gene: CBX2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	28514442, 27705803, 33961781, 22325352, 24981860, 37014752
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1004 Hs			1 532
+	Mm
		675498 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84
+	Hs
		123234 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Hs
		1059204 SCML2_HUMAN (590-1003): 5.22e-31: 132: 16.14		CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00
+	Hs
		1059182 SCMH1_HUMAN (572-1003): 4.16e-28: 123: 15.94		CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00
+	Hs
		123346 SCML2_HUMAN (590-1003): 5.22e-31: 132: 16.14		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Hs
		123303 SCMH1_HUMAN (572-1003): 4.16e-28: 123: 15.94		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Hs
		316005 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Hs
		943094 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		327838 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		CBX7_HUMAN (3-210): 1.4e-35: 135: 27.98
+	Hs
		69543 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		B0QXZ6_HUMAN (3-242): 5.28e-30: 123: 28.63
+	Mm
		1144861 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		CBX7_MOUSE (3-117): 1.22e-29: 115: 42.24
+	Hs
		949813 ADNP2_HUMAN (319-823): 1.29e-45: 180: 14.91		CBX1_HUMAN (18-153): 1.81e-38: 141: 22.79
+	Hs
		1027053 ADNP2_HUMAN (319-823): 1.29e-45: 180: 14.91		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		800419 ADNP2_HUMAN (319-823): 1.29e-45: 180: 14.91		CBX5_HUMAN (12-152): 1.24e-35: 133: 24.66
+	Hs
		316204 SCML2_HUMAN (590-1003): 5.22e-31: 132: 16.14		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Hs
		1335794 SCML2_HUMAN (590-1003): 5.22e-31: 132: 16.14		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		1027335 SCML2_HUMAN (590-1003): 5.22e-31: 132: 16.14		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		316124 SCMH1_HUMAN (572-1003): 4.16e-28: 123: 15.94		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Dm
		639970 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		PC_DROME (11-158): 2.02e-16: 83: 23.84
+	Dm
		639953 PHP_DROME (36-1003): 2.95e-29: 128: 15.26		PC_DROME (11-158): 2.02e-16: 83: 23.84