HitPredict

Interactor 1: PHC1 (P78364)
Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)
Gene: PHC1

Interactor 2: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	32296183, 24981860, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1004 Hs			1 242
+	Hs
		717684 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76
+	Hs
		718390 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03
+	Mm
		639473 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		BMI1_MOUSE (3-238): 5e-59: 191: 33.48
+	Mm
		620786 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		PCGF2_MOUSE (3-238): 2.56e-56: 184: 34.18
+	Hs
		943087 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		PCGF1_HUMAN (3-238): 1.66e-45: 154: 38.33
+	Hs
		943088 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		PCGF6_HUMAN (3-235): 4.63e-43: 150: 33.62
+	Hs
		943070 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		PCGF5_HUMAN (4-241): 3.95e-40: 140: 38.06
+	Hs
		943084 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		RING2_HUMAN (2-237): 3.42e-36: 132: 18.00
+	Hs
		943060 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Hs
		943066 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		Q5T8Z6_HUMAN (3-102): 2.37e-37: 128: 51.00
+	Mm
		1144863 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		RING2_MOUSE (2-237): 2.47e-36: 132: 18.00
+	Hs
		554277 MUC1_HUMAN (5-886): 1.17e-47: 187: 9.75		BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76
+	Mm
		639480 PHC2_MOUSE (186-1004): 2.37e-44: 175: 22.38		BMI1_MOUSE (3-238): 5e-59: 191: 33.48
+	Mm
		620794 PHC2_MOUSE (186-1004): 2.37e-44: 175: 22.38		PCGF2_MOUSE (3-238): 2.56e-56: 184: 34.18
+	Dm
		1341979 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		Q9VV77_DROME (2-241): 5.3e-50: 164: 54.55
+	Mm
		193416 PHC2_MOUSE (186-1004): 2.37e-44: 175: 22.38		RING1_MOUSE (3-182): 7.06e-36: 133: 20.22
+	Mm
		1321743 PHC2_MOUSE (186-1004): 2.37e-44: 175: 22.38		RING2_MOUSE (2-237): 2.47e-36: 132: 18.00
+	Dm
		728804 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		PSC_DROME (4-237): 4.98e-45: 162: 32.49
+	Dm
		627168 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		SUZ2_DROME (8-239): 2.05e-40: 149: 24.90
+	Dm
		1341975 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		RING1_DROME (3-128): 9.81e-30: 116: 20.93