HitPredict

Interactor 1: PHC1 (P78364)
Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)
Gene: PHC1

Interactor 2: SCML1 (Q9UN30)
Sex comb on midleg-like protein 1
Gene: SCML1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 27705803, 33961781, 22325352
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SAM_1~SAM_1
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0042393 - histone binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1004 Hs			1 329
+	Hs
		943097 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		SMBT1_HUMAN (25-322): 1.85e-86: 279: 23.17
+	Hs
		943067 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		SMBT2_HUMAN (25-322): 5.07e-80: 262: 21.21
+	Hs
		943082 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		SCMH1_HUMAN (131-325): 1.54e-46: 168: 30.85
+	Mm
		1144860 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		SCMH1_MOUSE (120-323): 2.88e-47: 171: 26.54
+	Hs
		1123979 Q59GP6_HUMAN (1-1004): 5.13e-86: 302: 99.90		Q59GP6_HUMAN (189-324): 5.69e-34: 134: 26.47
+	Hs
		943059 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		PHC1_HUMAN (189-324): 4.41e-34: 134: 26.47
+	Hs
		943073 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		PHC2_HUMAN (146-324): 1.16e-33: 133: 19.23
+	Hs
		943078 PHC1_HUMAN (1-1004): 1.29e-86: 302: 100.00		PHC3_HUMAN (162-324): 7.6e-33: 130: 21.47
+	Mm
		1144864 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		PHC2_MOUSE (159-324): 1.09e-33: 133: 21.30
+	Mm
		1144856 PHC1_MOUSE (1-1004): 1.64e-80: 284: 91.58		PHC1_MOUSE (189-324): 1.76e-33: 132: 27.21
+	Hs
		1292157 SMBT1_HUMAN (826-1002): 3.82e-35: 146: 28.57		SCMH1_HUMAN (131-325): 1.54e-46: 168: 30.85
+	Hs
		1164476 SMBT1_HUMAN (826-1002): 3.82e-35: 146: 28.57		SAMD1_HUMAN (119-329): 1.92e-46: 166: 15.64
+	Dm
		764508 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		PHP_DROME (148-323): 2.31e-36: 141: 22.16
+	Hs
		1295449 SMBT1_HUMAN (826-1002): 3.82e-35: 146: 28.57		LMBL3_HUMAN (136-325): 6.64e-35: 136: 20.00
+	Hs
		1220902 SMBT1_HUMAN (826-1002): 3.82e-35: 146: 28.57		PHC2_HUMAN (146-324): 1.16e-33: 133: 19.23
+	Dm
		1341976 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		SCM_DROME (169-321): 7.49e-32: 127: 25.63
+	Hs
		1139331 SMBT1_HUMAN (826-1002): 3.82e-35: 146: 28.57		SAM13_HUMAN (211-329): 1.42e-33: 121: 25.21
+	Dm
		1341978 Q9NF31_DROME (410-1003): 2.44e-34: 145: 19.97		SMBT_DROME (108-322): 9.27e-28: 115: 19.54