HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: TCAB1 (Q9BUR4)
Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)
Gene: WRAP53

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26496610, 33961781, 25467444
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0051973 - positive regulation of telomerase activity GO:0090666 - scaRNA localization to Cajal body GO:1904851 - positive regulation of establishment of protein localization to telomere
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 548
+	Hs
		1306653 TCPH_HUMAN (4-532): 0: 591: 34.08		TCAB1_HUMAN (1-548): 2.69e-107: 333: 98.37
+	Hs
		1306645 TCPH_HUMAN (4-532): 0: 591: 34.08		TBL1Y_HUMAN (274-548): 1.31e-49: 180: 15.75
+	Hs
		943437 TCPB_HUMAN (1-535): 0: 586: 100.00		TBL1Y_HUMAN (274-548): 1.31e-49: 180: 15.75
+	Hs
		267753 TCPB_HUMAN (1-535): 0: 586: 100.00		TAF5L_HUMAN (234-534): 1.86e-43: 164: 13.92
+	Hs
		197078 TCPH_HUMAN (4-532): 0: 591: 34.08		PRP4_HUMAN (305-548): 2.59e-40: 155: 14.74
+	Hs
		1202777 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5B_HUMAN (361-541): 2.58e-41: 153: 12.16
+	Hs
		197001 TCPB_HUMAN (1-535): 0: 586: 100.00		PRP4_HUMAN (305-548): 2.59e-40: 155: 14.74
+	Hs
		943328 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5B_HUMAN (361-541): 2.58e-41: 153: 12.16
+	Sc
		744616 TCPB_YEAST (9-532): 0: 566: 65.71		TAF5_YEAST (316-534): 2.78e-40: 157: 17.37
+	Hs
		921697 TCPH_HUMAN (4-532): 0: 591: 34.08		GBB2_HUMAN (341-546): 6.74e-33: 130: 12.62
+	Hs
		921522 TCPB_HUMAN (1-535): 0: 586: 100.00		GBB2_HUMAN (341-546): 6.74e-33: 130: 12.62
+	Hs
		1306704 TCPH_HUMAN (4-532): 0: 591: 34.08		NLE1_HUMAN (51-257): 2.3e-27: 117: 11.59
+	Hs
		943508 TCPB_HUMAN (1-535): 0: 586: 100.00		NLE1_HUMAN (51-257): 2.3e-27: 117: 11.59
+	Hs
		903467 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5_HUMAN (455-548): 1.44e-18: 88.9: 9.57
+	Hs
		903120 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5_HUMAN (455-548): 1.44e-18: 88.9: 9.57
+	Hs
		943403 TCPB_HUMAN (1-535): 0: 586: 100.00		SNR40_HUMAN (445-548): 4.84e-18: 87.7: 11.43
+	Dm
		186253 Q9W392_DROME (4-535): 0: 568: 70.73		GBLP_DROME (259-482): 1.74e-23: 103: 16.96
+	Hs
		943370 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1B_HUMAN (457-548): 7.7e-16: 82: 11.96
+	Hs
		1240450 TCPH_HUMAN (4-532): 0: 591: 34.08		POC1A_HUMAN (99-199): 3.27e-12: 70.4: 6.93
+	Hs
		943355 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1A_HUMAN (99-199): 3.27e-12: 70.4: 6.93