HitPredict

Interactor 1: KRT85 (P78386)
Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)
Gene: KRT85

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 507 Hs			1 530
+	Hs
		368794 K2C1_HUMAN (92-448): 8.37e-123: 375: 54.44		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		213976 KRT86_HUMAN (7-501): 1.59e-101: 315: 81.65		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368816 K2C8_HUMAN (46-461): 7.91e-114: 346: 53.61		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		318855 K2C75_HUMAN (3-437): 4.67e-87: 279: 49.78		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1062061 K2C72_HUMAN (10-507): 6.8e-80: 260: 43.65		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		580147 K2C4_HUMAN (7-453): 8.43e-69: 231: 47.32		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		280820 KRT36_HUMAN (28-434): 1.29e-68: 229: 26.47		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369795 K2C79_HUMAN (22-454): 8.92e-83: 268: 46.67		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368958 K2C4_HUMAN (7-453): 8.43e-69: 231: 47.32		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370133 KRT35_HUMAN (28-482): 1.18e-66: 223: 25.05		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487082 K2C3_HUMAN (95-434): 2.72e-128: 388: 58.14		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		408982 K2C8_HUMAN (46-461): 7.91e-114: 346: 53.61		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59