HitPredict

Interactor 1: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Interactor 2: TYRO3 (Q06418)
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
Gene: TYRO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 4128 Hs			1 890
+	Hs
		665578 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		EPHB2_HUMAN (72-826): 1.04e-178: 546: 20.21
+	Hs
		944192 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		TIE2_HUMAN (37-796): 3.68e-160: 499: 23.35
+	Hs
		600550 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		EPHA1_HUMAN (203-829): 5.58e-141: 445: 26.19
+	Hs
		435610 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53
+	Hs
		944196 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		RON_HUMAN (500-793): 2.58e-59: 223: 41.95
+	Hs
		445842 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		ROS1_HUMAN (279-787): 2.73e-55: 211: 30.76
+	Hs
		337429 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		ABL1_HUMAN (519-878): 6.21e-54: 205: 36.76
+	Hs
		713782 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		RYK_HUMAN (503-782): 8.78e-55: 202: 37.50
+	Hs
		601494 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		FGFR2_HUMAN (2-234): 1.07e-43: 172: 13.68
+	Hs
		609246 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		FGFR3_HUMAN (7-315): 1.59e-17: 89.8: 14.60
+	Hs
		674388 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		UFO_HUMAN (6-344): 1.91e-14: 79.8: 14.56
+	Hs
		944208 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		MERTK_HUMAN (6-315): 1.52e-12: 73.6: 15.71
+	Hs
		872435 ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42		EPHA5_HUMAN (125-818): 6.7e-176: 538: 20.30
+	Hs
		445886 TRRAP_HUMAN (2754-4128): 0: 828: 15.88		ROS1_HUMAN (279-787): 2.73e-55: 211: 30.76
+	Hs
		337382 MTOR_HUMAN (2776-4127): 0: 695: 15.99		ABL1_HUMAN (519-878): 6.21e-54: 205: 36.76
+	Hs
		600653 SMG1_HUMAN (3179-4115): 6.6e-124: 444: 16.20		EPHA1_HUMAN (203-829): 5.58e-141: 445: 26.19
+	Hs
		337460 ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42		ABL1_HUMAN (519-878): 6.21e-54: 205: 36.76
+	Hs
		337465 ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28		ABL1_HUMAN (519-878): 6.21e-54: 205: 36.76