HitPredict

Interactor 1: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005524 - ATP binding GO:0007507 - heart development
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 4128 Hs			1 839
+	Hs
		384640 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		609246 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		601494 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	Hs
		944267 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		435610 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		787493 MTOR_HUMAN (2776-4127): 0: 695: 15.99		NTRK3_HUMAN (1-839): 0: 671: 100.00