HitPredict

Interactor 1: BTG2 (P78543)
Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
Gene: BTG2

Interactor 2: CNOT8 (Q9UFF9)
CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b)
Gene: CNOT8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.837

Property	Details
Experiments	11136725, 25416956
Identification Methods	two hybrid, pull down, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BTG~CAF1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 292
+	Mm
		978995 BTG2_MOUSE (1-158): 7.04e-87: 252: 93.67		CNOT8_MOUSE (1-292): 0: 516: 99.32
+	Mm
		912802 BTG1_MOUSE (3-158): 1.05e-77: 229: 62.05		CNOT8_MOUSE (1-292): 0: 516: 99.32
+	Hs
		1152298 Q6IBC8_HUMAN (3-158): 1.05e-77: 229: 62.05		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		912793 BTG1_HUMAN (3-158): 1.05e-77: 229: 62.05		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		944599 BTG2_HUMAN (1-158): 4.64e-87: 253: 100.00		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Mm
		978994 BTG2_MOUSE (1-158): 7.04e-87: 252: 93.67		CNOT7_MOUSE (1-282): 2.93e-175: 486: 76.60
+	Mm
		912801 BTG1_MOUSE (3-158): 1.05e-77: 229: 62.05		CNOT7_MOUSE (1-282): 2.93e-175: 486: 76.60
+	Hs
		1152299 Q6IBC8_HUMAN (3-158): 1.05e-77: 229: 62.05		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Hs
		912794 BTG1_HUMAN (3-158): 1.05e-77: 229: 62.05		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Hs
		841403 TOB1_HUMAN (9-123): 3.98e-57: 183: 42.61		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		1048316 TOB2_HUMAN (9-123): 3.81e-53: 173: 40.87		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Mm
		251046 BTG4_MOUSE (9-116): 1.05e-47: 156: 41.82		CNOT8_MOUSE (1-292): 0: 516: 99.32
+	Hs
		841404 TOB1_HUMAN (9-123): 3.98e-57: 183: 42.61		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Hs
		1051204 BTG3_HUMAN (9-116): 2.96e-44: 147: 43.64		CNOT8_HUMAN (1-292): 0: 514: 100.00
+	Hs
		1048317 TOB2_HUMAN (9-123): 3.81e-53: 173: 40.87		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Mm
		251045 BTG4_MOUSE (9-116): 1.05e-47: 156: 41.82		CNOT7_MOUSE (1-282): 2.93e-175: 486: 76.60
+	Hs
		1051207 BTG3_HUMAN (9-116): 2.96e-44: 147: 43.64		CNOT7_HUMAN (1-282): 1.23e-174: 485: 76.24
+	Dm
		1155377 Q6NQY2_DROME (9-125): 1.17e-51: 173: 39.32		Q9VTS4_DROME (2-277): 3.72e-156: 439: 66.55
+	Dm
		60235 A4V4L0_DROME (9-125): 6.52e-49: 166: 40.17		X2JCC3_DROME (2-244): 4.52e-145: 413: 69.39