HitPredict

Interactor 1: DRB3 (P79483)
HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3)
Gene: HLA-DRB3

Interactor 2: HFE (Q30201)
Hereditary hemochromatosis protein (HLA-H)
Gene: HFE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~C1-set, C1-set~MHC_I, C1-set~MHC_II_beta
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 266 Hs			1 348
+	Hs
		382442 DRB5_HUMAN (1-266): 6.25e-98: 289: 86.84		HLAA_HUMAN (7-346): 1.33e-140: 404: 36.42
+	Hs
		382387 DRB3_HUMAN (1-266): 9.27e-96: 283: 100.00		HLAA_HUMAN (7-346): 1.33e-140: 404: 36.42
+	Hs
		355008 DQB1_HUMAN (3-255): 3.04e-92: 274: 61.27		HLAA_HUMAN (7-346): 1.33e-140: 404: 36.42
+	Hs
		354928 DRB1_HUMAN (1-266): 5.78e-99: 291: 89.10		HLAG_HUMAN (7-336): 4.39e-127: 369: 35.42
+	Hs
		570318 DRB3_HUMAN (1-266): 9.27e-96: 283: 100.00		HLAG_HUMAN (7-336): 4.39e-127: 369: 35.42
+	Hs
		382580 DPB1_HUMAN (1-259): 1.02e-94: 280: 59.46		HLAG_HUMAN (7-336): 4.39e-127: 369: 35.42
+	Hs
		354925 DRB1_HUMAN (1-266): 5.78e-99: 291: 89.10		HLAC_HUMAN (21-310): 5.15e-121: 355: 37.29
+	Hs
		488244 DRB5_HUMAN (1-266): 6.25e-98: 289: 86.84		HLAC_HUMAN (21-310): 5.15e-121: 355: 37.29
+	Hs
		355013 DQB1_HUMAN (3-255): 3.04e-92: 274: 61.27		HLAG_HUMAN (7-336): 4.39e-127: 369: 35.42
+	Hs
		354932 DRB1_HUMAN (1-266): 5.78e-99: 291: 89.10		HLAF_HUMAN (7-346): 8.17e-119: 348: 35.26
+	Hs
		354926 DRB1_HUMAN (1-266): 5.78e-99: 291: 89.10		HLAE_HUMAN (21-316): 4.13e-118: 347: 36.42
+	Hs
		488189 DRB3_HUMAN (1-266): 9.27e-96: 283: 100.00		HLAC_HUMAN (21-310): 5.15e-121: 355: 37.29
+	Hs
		354242 DQB1_HUMAN (3-255): 3.04e-92: 274: 61.27		HLAB_HUMAN (7-347): 2.87e-124: 363: 36.02
+	Hs
		382598 DPB1_HUMAN (1-259): 1.02e-94: 280: 59.46		HFE_HUMAN (1-348): 2.1e-121: 355: 100.00
+	Hs
		673951 DRB3_HUMAN (1-266): 9.27e-96: 283: 100.00		HLAF_HUMAN (7-346): 8.17e-119: 348: 35.26
+	Hs
		533138 DRB3_HUMAN (1-266): 9.27e-96: 283: 100.00		HLAE_HUMAN (21-316): 4.13e-118: 347: 36.42
+	Hs
		355010 DQB1_HUMAN (3-255): 3.04e-92: 274: 61.27		HLAC_HUMAN (21-310): 5.15e-121: 355: 37.29
+	Hs
		382578 DPB1_HUMAN (1-259): 1.02e-94: 280: 59.46		HLAE_HUMAN (21-316): 4.13e-118: 347: 36.42
+	Hs
		355019 DQB1_HUMAN (3-255): 3.04e-92: 274: 61.27		HLAF_HUMAN (7-346): 8.17e-119: 348: 35.26
+	Hs
		354975 DRB1_HUMAN (1-266): 5.78e-99: 291: 89.10		HMR1_HUMAN (9-345): 1.42e-107: 319: 36.10